Genistein, an epigenome modifier during cancer prevention

Epigenome, Cancer Prevention and Flavonoids and Curcumin

Targeting the epigenome with bioactive food components for cancer prevention.

Epigenetic processes participate in cancer development and likely influence cancer prevention. Global DNA hypomethylation, gene promoter hypermethylation and aberrant histone post-translational modifications are hallmarks of neoplastic cells which have been associated with genomic instability and altered gene expression. Because epigenetic deregulation occurs early in carcinogenesis and is pote...

Impact of Soy Isoflavones on the Epigenome in Cancer Prevention

Isoflavones (IF) such as genistein are cancer preventive phytochemicals found in soy and other legumes. Epidemiological studies point to a reduced risk for hormone‑dependent cancers in populations following a typical Asian diet rich in soy products. IF act as phytoestrogens and prevent tumorigenesis in rodent models by a broad spectrum of bioactivities. During the past 10 years, IF were shown t...

A blueprint for an international cancer epigenome consortium. A report from the AACR Cancer Epigenome Task Force.

Recent whole-genome sequencing of thousands of human cancers has uncovered an unexpectedly large number of mutations in genes, which control the epigenome. Many of these recurrent mutations are in epigenetic writers (e.g., EZH2, DNMT3a), readers (BRD4-NUT fusions), erasers (UTX mutations), and chromatin remodeling enzymes (BAF subunits of SWI/SNF). They occur at high frequencies and may therefo...

Epigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenome.

Aberrant epigenetic alterations in the genome such as DNA methylation and chromatin remodeling play a significant role in breast cancer development. Since epigenetic alterations are considered to be more easily reversible compared to genetic changes, epigenetic therapy is potentially very useful in reversing some of these defects. Methylation of CpG islands is an important component of the epig...